Collectively, these studies demonstrate that Sch B and SCF exhibit dose-dependent toxicity, primarily manifesting as hepatomegaly, oxidative stress, and dysregulated lipid metabolism
In vitro , the viability of human astrocytes is improved with 15 mmol/L glucose treatment, but astrocytes are damaged by 30 mmol/L glucose, with changes in the morphology and expression of cytoskeletal proteins, such as GFAP and vimentin
10.1002/aisy.202300366 Adv
There are many other possible causes of acanthosis nigricans, including: Addison's disease, a condition caused by a deficiency of hormones from the adrenal gland Disorders of the pituitary gland within the brain Growth hormone therapy Hypothyroidism (low levels of thyroid hormone caused by lowered activity of the thyroid gland) Oral contraceptives Polycystic ovary syndrome, a hormonal imbalance problem in people assigned female at birth Corticosteroid medications Autoimmune conditions like lupus and Sjogren's syndrome Most people with acanthosis nigricans have an insulin level that is higher than that of people of the same weight who don't have acanthosis nigricans
