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Since TMAO plays a significant role in heart failure (HF) pathogenesis, one of several cardiovascular diseases (CVDs) caused by vascular inflammation, it can serve as an early and timely prognostic biomarker before HF becomes critical 81, 133, 134

Through the LCT program, Wyse and his team annually evaluate dossier submissions to identify promising candidates for clinical trials, spanning the United States, Australia, the United Kingdom, and mainland Europe