It is therefore possible that oxidant stress reduces remethylation and enhances transsulfuration to maintain, via an autocorrective process, the intracellular glutathione pool, which would be essential for the redox-regulating capacity of cells
PLoS ONE 7 , e36948 (2012)
The bulk of the hair-relevant data is in vitro (cells in dishes) or ex vivo (isolated follicles in culture), andas we will seea large share of the most-cited follicle-elongation evidence used a closely related but distinct peptide, AHK-Cu, not GHK-Cu itself
We generated a heat map of 16 differentially expressed transcripts involved in glutathione metabolism, including Gsta1 , Gclc , Gclm , Gsta3 , Gsta4 , Gpx2 , Odc1 , Rrm2 , Rrm1 , Mgst2 , Gstp1 , Gsr , Srm , Gsta2 , Gss and Mgst1 (Figure 2c)