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Nutr Rev 2017;75(7):491499

Tirzepatide is an imbalanced agonist, engaging the GIPR to a greater degree than the GLP-1R in cultured cell systems

In aging, mitochondrial DNA is susceptible to oxidative damage due to increased levels of ROS (32),and is associated with a 17-fold higher rate of mutations compared with nuclear DNA (33)

The L-Theanine amino acid promotes relaxation without sedation and may increase levels of GABA, serotonin, and dopamineneurotransmitters involved in mood and neural stability