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The collagen story is really a remodeling story The first clean fibroblast result landed in 1988, when Maquart and colleagues reported in FEBS Letters that GHK-Cu pushed cultured skin fibroblasts to make more collagen at concentrations as low as 10 M

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Table 2 Application of various mechanical stimuli on synovial fibroblasts, including types of forces, application methods, time intervals, and observed effects