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Byetta was not very popular due to its twice-a-day format, its delivery via a large needle and significant gastrointestinal side effects, for only moderate efficacy in lowering glucose levels

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The development of oral glucagon like peptide 1 analogs offers a transformative opportunity to enhance patient convenience, improve compliance, and expand the target demographic, particularly among individuals with needle aversions or injection phobia

[46] A 2024 systematic review of 6 studies found that while lean body mass was unchanged in some cases, there were instances of significant decreases in lean body mass (040%)