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The SURPASS-1 through SURPASS-5 trials demonstrated that 91% of patients on tirzepatide achieved an A1C below 7% (the standard treatment target), compared to approximately 68% on liraglutide in comparable studies

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However, central administration of LEAP2 reduces binge-like intake of a HFD, an effect not observed with central ghrelin administration or with pharmacological blockade of GHSR using the antagonists [D-Lys3]-GHRP-6 and JMV2959