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Limitations include heterogeneity in study designs, populations, and outcome measures, which may affect generalizability and preclude definitive causal conclusions

A 2025 commentary in Diabetes Care similarly suggested that individualized dosing approaches may help some patients remain on treatment when standard dosing isn't ideal

J.Reyes-RiveraI.ZhuJ.et al (2011)

Contemporary trial data in high risk patient groups do not show convincing evidence that intensive lipid lowering causes major neurocognitive harm, dementia, or a clear excess of haemorrhagic stroke in selected patients, even at very low achieved LDL-C levels [9], [10], [11], [12], [13], [14], [15], [16]