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Estrogen can enhance autoimmune responses, which partly explains the female predominance of the disease

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However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

Brightening skin due to hormonal or pregnancy related changes (called the mask of pregnancy or melasma) can be challenging