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OConnor 2003)

FIGURE 7 4.5 Multimodal synergistic therapy As mentioned above, we clearly recognize that GSH-responsive and -exhausting metal nanomedicines have a prominent effect on cancer therapy

If left unchecked, lipid peroxidation destroys the structural integrity of the mitochondria and triggers a highly inflammatory form of programmed cell death known as ferroptosis, a mechanism heavily implicated in the pathophysiology of ME/CFS

In alternative pathways, the 13 S -lipoxygenase metabolite can be reduced to a hydroxy acid, while a peroxygenase or pathogen-induced oxygenase pathway is another route to the biosynthesis of epoxy-hydroxy fatty acids