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However, glucagon itself has recently been shown to be able to stimulate insulin secretion from the perfused mouse pancreas by a mechanism which appears to involve an interaction with GLP-1 receptors (since the effect was attenuated by exendin 9-39) (111), complicating assessment of the relative importance of any locally produced GLP-1

Some signs and symptoms are only described in a few case reports, and include peripheral neuropathy involving both upper and lower limbs, mild developmental delay, anemia, respiratory distress and proximal muscle weakness [65,66,67]

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