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Glutathione synthetase deficiency has been incriminated as the cause of chronic hemolytic anemia alone (due to isolated RBC enzyme deficiency) and as the cause of a generalized syndrome (due to enzyme deficiency in many tissues) characterized by mild hemolytic disease, severe metabolic acidosis, and mental deterioration

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"Deficiencies in these vitamins, while rare in normal Western diets, have been shown to cause premature graying, so if a vitamin deficiency is identified, correcting it could help prevent early graying." Can hair products like shampoo reverse gray

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