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Across preclinical research, BPC-157 has been reported to have a favorable tolerability profile: a 2021 Frontiers in Pharmacology review noted no reported toxicity in animal studies, with the LD1 (lethal dose for 1% of animals) not reached
But one less obvious factor worth considering: vitamin B12 deficiency
In particular, commenters expressed concerns about the specific instruction, in the definition of the median allowed amount and the 10th and 90th percentile allowed amounts, stating that should the calculated percentile fall between two observed allowed amounts, the percentile allowed amount is the next highest observed value. These commenters indicated this deviation from the standard way of calculating a percentile when it falls between two observed values would require hospitals to implement custom formulas for these calculations rather than the out-of-the-box formulas, increasing hospital burden
The compounded 60 mg format offers cost savings but does not carry the same regulatory oversight
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