Dysesthesia is abnormal touch sensation tingling, numbness, or unusual skin sensitivity reported in 12.520.9% of retatrutide patients at 12mg (varying by trial population), versus less than 1% with tirzepatide or semaglutide
Contains beneficial ingredients like glutathione, vitamin C, and aloe vera
Abbreviations: VTA: ventral tegmental area, NAc: nucleus accumbens, NTS: nucleus tractus solitarius, LH: lateral hypothalamus, DMHipp: dorsomedial hippocampus, LDTg: laterodorsal tegmental nucleus, LS: lateral septum, CeA: central amygdala, PVN: paraventricular nucleus, DA: dopamine, : decreased, : increased, MAO-A: monoamine oxidase A, COMT: catechol-O-methyltransferase, D1-MSN: D1-type medium spiny neuron, OX1R: orexin-1 receptor, HPA: hypothalamicpituitaryadrenal axis
Cell 21 , 775785 (2006)