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Similarly, the antitumor properties of KD are correlated with the downregulation of pyruvate kinase M2 (PKM2) expression levels, a key enzyme that limits the rate of glycolysis ( Furthermore, the following studies have demonstrated an overexpression of matrix metalloproteinases (MMP-1, 2, 3, 7, 9 and 13) in human colorectal cancer ( Numerous studies have demonstrated the relationship between KD, KBs and the suppression of histone deacetylases (HDACs) expression in human tumors ( Cell proliferation and apoptosis are also controlled by the nuclear transcription factor p53 ( 3.2 Metabolic effect of FMD Another dietary intervention that has been studied in cancer patients to improve quality of life, regulate tumor growth, and improve tolerance to side effects of anticancer treatments is FMD