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Stimulation of PI hydrolysis and Ca 2+ release OA selectively activated G s , and treatment of myo-[ 3 H]inositol labeled cells with OA resulted in an increase in PI hydrolysis in a concentration-dependent manner with an EC 50 of 0.83 0.15 M and a maximal stimulation of 8715 1024 cpm/mg protein above basal levels (1856 302 cpm/mg protein) with 10 M OA (Figure 3D)

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IRB and IACUC Protocols: Researchers conducting animal model studies with peptides are required to obtain appropriate Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC) approvals