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Debilitating Fatigue: By halting the oxidative damage to mitochondrial membranes, S-A-GSH allows the electron transport chain to resume efficient ATP production, helping to lift the heavy, leaden feeling of profound cellular exhaustion

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For instance, disruption of circadian rhythms by repeated advances in the light-dark schedule in rodent models consistently altered expression of core clock genes such as Per2 and Bmal1, leading to impaired immune function, including reduced NK cell cytotoxicity and decreased expression of cytolytic factors like IFN, perforin, and granzyme B

Pickart, L., Vasquez-Soltero, J