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Conclusion This review elucidated the significance of the metabolism-inflammation-oxidative stress axis in the occurrence and development of OA, and also dialectically discussed the mechanisms and clinical benefits of beneficial nutrients in the treatment of OA

The relatively small sample size (44 participants) may have limited the generalizability of the findings

These may include: High Production Costs: Due to the intricacy of peptide synthesis and purification, the manufacture of copper peptide GHK-Cu is expensive

In the presence of sufficient quantities of antioxidants, however, free radicals and oxidative stress can be minimized