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doi: 10.2174/1566524023666230818142831

To determine the optimal supplemental dosage and duration for treating fibrosis in different organs, as well as the possibility of hepatorenal toxicity when used over an extended period of time, more preclinical research is still required to support the data, and clinical studies are needed to produce high-caliber evidence-based research

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De Simone R, Ajmone-Cat MA, Carnevale D, Minghetti L (2005) Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures