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doi: 10.1210/jcem.78.3.8126144 138 ImbimboBPMantTEdwardsMAminDDaltonNBoutignonFet al

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Factors that might warrant dose adjustment include body weight (with some research using weight-based dosing of 0.5-1.0 mcg/kg), response to first doses (with increases if effects are suboptimal or decreases if adverse effects occur), research phase (with possible dose increases in later phases of long-term protocols), and mix with other research compounds (which may need dose adjustments to account for combined effects)