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TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11

Minor increases in liver enzymes seen in Phase I trials in volunteers may be related to changes in diet, exercise pattern and environment, as noted above, but the possibility of a drug-induced change should not be ruled out, especially if similar changes have been noted in the non-clinical studies

Instead, they use plant-based ingredients like berberine and chromium, which support metabolism and appetite control

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