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Excessive mitochondrial activity, and in particular large swings from high to low mitochondrial activity as would happen after a burst of glutamate release followed by inhibition by extra synaptic metabotropic receptors (Figures 1B,C), has been shown to lead to the largest amount of ROS production by mitochondria ( 2+ , which impairs mitochondrial energetics and initiates cytoskeletal degradation

Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, et al

Alcoholic ketoacidosis (also referred to as alcoholic ketosis or alcoholic acidosis) manifests with nausea, intractable vomiting, and abdominal pain

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