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Oral B12 (given sublingually) MB12 liquid The research used 500 mcg per day Although B12 is a very safe vitamin, always be on the lookout for these symptoms when using high doses: Headache Nausea and vomiting Diarrhea Fatigue or weakness Tingling sensation in hands and feet Possible explanations for elevated B12 (without supplementation) in the blood SIBO (Small Intestine Bacterial Overgrowth) SIBO may cause very elevated levels of B12 in the blood