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In HBV and HCV, persistent mitochondrial stress drives hepatocyte apoptosis, fibrosis, and hepatocarcinogenesis (Kim et al., 2014

While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)

Therefore, diagnosis, monitoring, frequency, severity and assessment of the prognosis for disease progression should be assessed before management decisions

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