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18 Prevention Because of potential interactions from prolonged medication use, physicians should consider screening patients for vitamin B 12 deficiency if they have been taking proton pump inhibitors or H 2 blockers for more than 12 months, or metformin for more than four months

At 10 percent concentration with the same application schedule, consumption rises to approximately 1.4 grams per month

This compound is provided as a lyophilized powder for reconstitution