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It should be pointed out, however, that while PVPA is a simple, reproducible method alternative to diffusion cell testing, it provides no insight into the mechanism of liposome action, as the content of the vesicles in the acceptor compartment is unknown [80]

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Risk-benefit analysis should consider the severity and impact of the condition being treated, failure or limitations of conventional therapies, individual patient risk factors particularly for malignancy, and patient preferences regarding experimental treatments

For many people, the question isn't whether any side effect appears