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GLP1 regulates plasma glucose level through stimulation of glucosedependent insulin secretion, suppress glucagon secretion, and delays gastric emptying with satiety promotion [1]

THE FIT PROGRAM INCLUDED ADULT PATIENTS WITH CHRONIC ITP WHO HAD RECEIVED 1 PRIOR THERAPY FIT program patients were representative of the general adult chronic ITP population, including exposure to prior therapies TAVALISSE dosing 3 Starting dose of TAVALISSE: One 100 mg tablet BID Based on platelet count and tolerability, the dose could be increased to one 150 mg tablet BID at or after week 4 Patients who had a platelet count 50 x 10 9 /L at the time of rollover to the FIT-3 open-label extension study maintained their existing dose of TAVALISSE References: 1

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This class of work reports that amylin-mimetic peptides adopt characteristic binding poses while inducing receptor-specific conformational dynamics, providing a molecular framework for interpreting the pharmacological differences between newer acylated analogs such as cagrilintide and older peptides in the family