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Across subgroups, the weight change was consistently larger for SGLT2i recipients than for GLP1-RA recipients

Microdosing GLP-1 for autoimmune conditions is an emerging area of interest, with some practitioners maintaining patients on very low doses primarily for anti-inflammatory benefits rather than weight management

In addition, both in vitro and in vivo Interleukin-6 (IL-6) has shown to be a powerful GLP-1 secretagogue, capable to positively modulate both the proglucagon gene, and the expression of PC1/3 in -cells and intestinal L-cells (225, 226)

Subcutaneous delivery supports controlled plasma concentration curves and predictable onset windows in human trials