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Branded versions such as Ozempic, Rybelsus, and Wegovy carry FDA approval for type 2 diabetes, cardiovascular risk reduction, and obesity treatment

Some studies have identified a correlation between T2DM and oxidative damage or antioxidant status [307,308,309]

PI3K/Akt pathway promotes cell survival and protein synthesis

As previously described, lactate secreted by PC cells is incorporated by TAMs in the TME, inducing the epigenetic change of histone lactylation and further reducing TAMs phagocytic and immunosuppressive effect on the tumor cells