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The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235

We focus on the hepatotoxicity and nephrotoxicity of EGCG and briefly summarize the other adverse effects of EGCG (gastrointestinal toxicity)

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Triple agonism addresses more of the obesity puzzle than single agonism