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10.1016/j.phymed.2023.154790 121 WuJ.WeiZ.ChengP.QianC.XuF.YangY.et al (2020)

Stabler 24 Patients with severe abnormalities should receive injections of 1000 g at least several times per week for 1 to 2 weeks, then weekly until clear improvement is shown, followed by monthly injections

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This pathway is involved in mitochondrial dynamics by decreasing cyclooxygenase 2 (COX-2) concentration and ROS-dependent Akt activation [28,34,48] Other antiapoptotic proteins that intervene in the process of mitochondrial apoptosis and whose activity can be regulated by melatonin are Bcl-2