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FDA-Approved Uses for Ozempic How Ozempic Works FDA-Approved Indication Ozempic (semaglutide) is FDA-approved for adults with type 2 diabetes mellitus: As an adjunct to diet and exercise to improve blood sugar control To reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes and known heart disease To reduce the risk of kidney disease worsening, kidney failure, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease Ozempic is not approved by the FDA for weight loss