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Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

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In addition, frail or older patients with sarcopenia are not eligible for GLP-1RA plus SGLT2i combination therapy, as it could induce rapid and great reductions in body weight [82]

10.1186/s12889-020-08662-0 6