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Diabetologia 48(9):17001713 Edwards K, Li X, Lingvay I (2023) Clinical and safety outcomes with GLP-1 receptor agonists and SGLT2 inhibitors in type 1 diabetes: a real-world study

People who live in areas with low levels of selenium or iodine, where a baseline shortage increases response because resolving baseline deficits can enhance antioxidant selenium enzyme activity (selenium), restore thyroid hormone synthesis and metabolism (iodine), and possibly lower thyroid autoimmunityas a result, effect sizes may seem larger in deficient settings than in replete populations [2,18,36,47]