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Optimal Ratios & Synergies: Certain nutrients compete for transporters (like zinc and copper) or work synergistically (B vitamins)

In a PD model, the modeled rats were observed with compromised BBB and markedly elevated IL-17A levels in the SN (Li et al., 2019)

Psychological barriers : Some patients experience frustration, get discouraged, or have anxiety related to treatment expectations and results, leading to nonadherence