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Investigations may include thyroid function tests (TSH, free T4), full blood count, ferritin, vitamin B12 and folate levels to exclude hypothyroidism or anaemia, both of which can cause cold intolerance and may require specific treatment

Applied topically, it uses the same mechanism to promote lipid breakdown in subcutaneous tissues, making it a valued active in treatments targeting cellulite

The medication's effect on blood glucose control is particularly relevant, as elevated glucose levels can create an environment conducive to certain types of infections, including fungal overgrowth

doi: 10.1016/j.ymgme.2022.07.010 60 KishnaniPSAustinSLAbdenurJEArnPBaliDSBoneyAet al