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Gut microbiota contribute to MASLD development through various mechanisms, including disruption of liver choline metabolism (necessary for VLDL synthesis and liver lipid export) (150), alterations in bile acid synthesis (151, 152), ethanol production (153), and increased lipopolysaccharides (LPS), which results in liver inflammation (154156)

Semaglutide binds to and activates GLP-1 receptors in pancreatic beta cells, enhancing glucose-dependent insulin secretion while suppressing inappropriate glucagon release

And to everyone's surprise, the horse won the race