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Indeed, it is known that hydrochlorothiazide can target several ion transporters and enzymes including SLC4A8 , a Na + -dependent Cl /HCO 3 exchanger (NDCBE), SLC26A4 , a Na + -independent Cl /HCO 3 exchanger (Pendrin) and carbonic anhydrases (Pickkers et al., 1999
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Angiogenesis: In addition, scientists examine its role in blood vessel formation using endothelial cells
Pathways for such a potential interaction are suggested in Figure 7
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