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However, the SURMOUNT-5 trial compared tirzepatide to semaglutide 2.4mg (a more potent GLP-1 agonist than liraglutide), and tirzepatide still showed superior weight loss: 20.2% vs 13.7% at 72 weeks

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Doctors now have a better toolkit: updated cutoffs, risk calculators that include zip code, and clearer protocols for who needs medication right away

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They may also require prior authorization or enforce quantity limits

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