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Thumbnail: Joe Rogan by Daniel Torok (Official White House Photo, Public Domain) References 1Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults | Teichman et al

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That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119