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Using the drug more frequently than approved (for example, daily rather than as-needed) or at higher doses adds repeated cardiovascular stress that, in a patient with borderline vascular health, could accelerate adverse remodeling

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Towards a high-throughput mouse model for opioid addiction Garret Stuber, Ph.D., University of Washington Opioid addiction has a tremendous toll on society, but a mechanistic understanding of how exposure to opioids such as heroin ultimately results in compulsive drug-taking and -seeking behavior in some individuals, but not others, is still poorly understood