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Consonant with this idea, it was shown that although homeostatic astrocytes have heterogeneous signatures in healthy individuals according to the CNS region, when they become reactive in MS, they undergo overlapping activation of pathways, mainly related to cell stress and immune activation (110)

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The initial step in this process is recognition by intracellular pattern recognition receptor (PRR) nucleotide-binding oligomerisation domain protein 1 (Nod 1) (36)