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Disease-associated dysbiosis and potential therapeutic role of Akkermansia muciniphila , a mucus degrading bacteria of gut microbiome

In an obese mouse model of diabetes, GLP-1 was shown to reduce macrophage infiltration and directly inhibit inflammatory pathways in adipocytes and adipose tissue macrophages (79)

In broader terms, the guidance exemplified how regulatory science can catalyze translational research, uncover unanticipated benefits, and accelerate innovation across therapeutic domains

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