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However, existing iron chelators exhibit side effects in clinical applications, including gastrointestinal discomfort, hepatotoxicity, and nephrotoxicity ( Based on TfR1-mediated iron uptake and ferroptosis mechanisms, researchers are exploring possibly delaying OA progression by intervening in ferroptosis

Human Clinical Trials Figure 2 summarizes ME-3s antioxidant effects in human clinical trials, listed as follows: 1

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