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The gut microbiome itself is changing during GLP-1 treatment through multiple mechanisms, providing biological rationale for considering targeted gut-microbiome support as a parallel layer to the medication

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Ragulator is anchored by lipidation of its LAMTOR1 subunit, and the lipid anchor is connected to the folded core of Ragulator by a 45-residue N-terminal disordered region 23,24,45,46,47 , with an estimated end-to-end length of ~47 on average and an extended length 48 of ~100 (Extended Data Fig