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Adverse reaction / Side effects: Rare allergic reactions (rash, itching, anaphylaxis)

Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action As a copper chelator, GHK-Cu modulates over 4,000 human genes, upregulating those involved in tissue remodeling (e.g., collagen I, III) and downregulating pro-inflammatory pathways like NF-B

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However, molecular analysis reveals that 126 DNA methylation sites remain altered (112), while 23 genes exhibit sustained expression changes (113), suggesting residual heritable effects that may contribute to long-term reproductive vulnerabilities