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A proposed mechanism in skin aging for the downregulation in procollagen biosynthesis is the impairment of the TGF-/Smads signaling pathway, since TGF- is a cytokine that contributes primarily to this process 24,25,26

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a Measure was assessed with the question: Based on what you see, which of these packs would you choose if you were most concerned about health? b Measure was assessed with the question: Based on what you see, which of these packs would you choose if you were most concerned about tar? c Measure was assessed with the question: Based on what you see, which of these packs would you choose if you were most concerned about nicotine? * Chi-square test of distribution (null assuming equal cell sizes) Chi-square tests also found that smokers consistently chose the whitest pack in both arrays (i.e., lowest E relative to white

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