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Case 2: A Bardet-Biedl syndrome patient with lifelong hyperphagia underwent combination therapy with 3mg setmelanotide and 5mg tirzepatide, leading to a severe food aversion, even to protein shakes, limiting their intake to fewer than 800 Calories daily

[PubMed] [Google Scholar] 155.Pfeiffer N., Traverso C.E., Lorenz K., Saarela V., Liinamaa J., Uusitalo H., Astakhov Y., Boiko E., Ropo A., Preservative-free Tafluprost/Timolol Fixed Combination Study Group A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components

In theory, the combination could achieve total weight reduction plus selective visceral fat targeting

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