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Males typically exhibit higher glomerular filtration rates (GFR), contributing to faster renal clearance of certain drugs, whereas females often experience reduced renal elimination, leading to prolonged drug half-lives and higher systemic exposure (Caldwell et al

Adding Prandial Insulin The aim of injecting RAIs just before a meal is to support basal-insulin action on FPG by controlling PPG excursions

1) further supports this response by upregulating AP-1, enhancing melanocyte resilience to oxidative stress 75

Personalized approaches tailored to individual biomarkers (Yang et al., 2017) and rigorous clinical validation through long-term studies (Power et al., 2012) will be essential for translating findings into effective therapies