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Scott Haak, PT, DPT, MTC, CSCS Medical Reviewer Scott Haak, PT, DPT, has been a member of the Mayo Clinic staff since 2000

Under the stimulation of lactate, the METTL3/YTHDC1 axis mediates the stability of ACSL4 mRNA through m6A modification, which leads to an increase in ACSL4, inducing ROS accumulation and mitochondrial-dependent ferroptosis, thereby exacerbating lactate-induced ferroptosis in pulmonary epithelial cells[209]